St. Patrick's Fife and Drum Band was founded in Wexford Town in 1893 by a group of seven gentlemen in Roche's Terrace, under the original name of St. Brigid's Fife and Drum Band. Stephen Sinnott and Michael Kehoe hosted the first official gathering and the following year the band made its first public appearance during the anniversary of the Manchester Martyrs.

The group played regularly at all manner and size of events, including funerals, unveilings, civic events, sporting events, and band contests until, like many organisations, it fell silent during the period of civil unrest in Ireland and the onset of World War I.

In 1922, Michael Kehoe, with the help of three of his founding co-members, reorganised the band under its current name and rebranded the band's membership, image, and community involvement.

The band's activities continued to expand from the 1930s and by the early 1960s band contests were reinvigorated in the southeast of the country. The band performed strongly in competitions and collected an impressive array of more than 30 titles in both regional band contests and senior flute band championships spanning from 1959 through 1993, not including multiple accolades dating back to 1902.

Colloquially known for many years as "The Boy's Band," the band made headlines as the first Irish fife and drum band to allow women to join. In 1981, Mrs. Margaret Beary paved the way for five other women to join the ranks, and she is still an integral member of the band. Today the band boasts a diverse membership of men and women, young and mature, including a strong legacy of several local families.

Additionally, the band shares its expertise and support with two sister bands, Thomas Francis Meagher Fife and Drum Band in Waterford and St. Mary's Prize Band in Limerick.

St. Patrick's Fife and Drum Band currently resides in Lower Bride Street, Wexford Town where it has maintained a strong presence since 1982.